E-Cadherin Antibody / CDH1
| Code | Size | Price |
|---|
| NSJ-RQ5389-100ul | 100 ul | £535.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit IgG
Antibody Clonality: Monoclonal
Antibody Clone: COH-3
Regulatory Status: RUO
Target Species:
- Human
- Mouse
- Rat
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store the E-Cadherin antibody at -20oC.
Documents
Further Information
Application Details :
Western blot: 1:1000-1:5000,Immunohistochemistry (FFPE): 1:50-1:200
Application Note:
Optimal dilution of the E-Cadherin antibody should be determined by the researcher.
Description:
The CDH1 gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. [RefSeq]
Format :
Purified
Formulation :
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Immunogen:
A synthetic peptide specific to human E-Cadherin / CDH1 was used as the immunogen for the E-Cadherin antibody.
Limitation:
This E-Cadherin antibody is available for research use only.
Localization:
Cytoplasmic, plasma membrane
Purity:
Affinity purified
Species Reactivity :
Human, Mouse, Rat
Uniprot #:
P12830