MUC1 Antibody / Mucin-1

Western blot: 1:1000-1:2000,Immunohistochemistry (FFPE): 1:50-1:200

Optimal dilution of the Mucin-1 antibody should be determined by the researcher.

The MUC1 gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. [RefSeq]

Purified

Antibody in PBS with 0.02% sodium azide and 50% glycerol

A synthetic peptide specific to the C-terminal region (beta subunit) of human MUC1 / Mucin-1 was used as the immunogen for the Mucin-1 antibody.

This Mucin-1 antibody is available for research use only.

Affinity purified

Human

P15941