ProSci

POLRMT (CT) Peptide

Product Code:
 
PSI-9561P
Product Group:
 
Peptides
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Application:
 
Blocking
Shipping:
 
Blue Ice
Storage:
 
Store ULBP1 peptide at -20˚C, stable for one year.
 

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CodeSizePrice
PSI-9561P-0.05mg0.05mg£166.00
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Further Information

Additional Names:
DNA-directed RNA polymerase, mitochondrial, MtRPOL, POLRMT Isoforms
Application Note:
POLRMT (CT) Peptide is used for blocking the activity of POLRMT (CT) Antibody.
Background:
POLRMT Antibody: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. POLRMT mutations impair mitochondrial transcription causing neurological disease. Knock-down of MRPL12 by RNA interference results in instability of POLRMT.
Background References:
  • Inatomi et al. Biochim Biophys Acta Mol Cell Res. 2022; 1869(1); 119167
  • Olahova et al. Nat Commun. 2021; 12(1):1135
  • Nouws et al. J Biol Chem 2016; 291(2):989-997
Buffer:
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Concentration:
200 ug/mL
NCBI Gene ID #:
5442
NCBI Official Name:
RNA polymerase mitochondrial
NCBI Official Symbol:
POLRMT
NCBI Organism:
Homo sapiens
Peptide aa Location:
11 amino acids near the carboxyl terminus of human POLRMT.
Physical State:
Liquid
Protein Accession #:
O0411.2
Protein GI Number:
50403691
Swissprot #:
O0411
User Note:
Optimal dilutions for each application to be determined by the researcher.

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