AB-680

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TargetMol
Product Code: TAR-T10216
Supplier: TargetMol
CodeSizePrice
TAR-T10216-1mg1mg£163.00
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TAR-T10216-2mg2mg£201.00
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TAR-T10216-5mg5mg£269.00
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TAR-T10216-1mL1 mL * 10 mM (in DMSO)£324.00
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TAR-T10216-10mg10mg£386.00
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TAR-T10216-25mg25mg£599.00
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TAR-T10216-50mg50mg£823.00
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TAR-T10216-100mg100mg£1,091.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-fold selectivity over related ectonucleotidases CD39.
CAS:
2105904-82-1
Formula:
C20H24ClFN4O9P2
Molecular Weight:
580.83
Pathway:
Immunology/Inflammation
Purity:
0.9798
SMILES:
C[C@H](Nc1cc(Cl)nc2n(ncc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O)c1ccccc1F
Target:
CD73

References

1. Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.