TargetMol

AES-135

Product Code:
 
TAR-T10255
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10255-1mg1mg£195.00
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TAR-T10255-5mg5mg£334.00
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TAR-T10255-1mL1 mL * 10 mM (in DMSO)£466.00
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TAR-T10255-10mg10mg£523.00
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TAR-T10255-25mg25mg£785.00
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TAR-T10255-50mg50mg£1,058.00
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Quantity:
TAR-T10255-100mg100mg£1,412.00
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Further Information

Bioactivity:
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
CAS:
2361659-61-0
Formula:
C33H29F6N3O5S
Molecular Weight:
693.66
Pathway:
DNA Damage/DNA Repair; Chromatin/Epigenetic
Purity:
0.9801
SMILES:
CC(C)(C)c1ccc(CN(C(=O)CN(Cc2c(F)c(F)c(F)c(F)c2F)S(=O)(=O)c2ccc(F)cc2)c2ccc(cc2)C(=O)NO)cc1
Target:
HDAC

References

1. Shouksmith AE, et al. Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. J Med Chem. 2019 Mar 14;62(5):2651-2665.