TargetMol

Antihistamine-1

Product Code:
 
TAR-T10335
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10335-1mg1mg£101.00
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TAR-T10335-5mg5mg£142.00
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TAR-T10335-1mL1 mL * 10 mM (in DMSO)£149.00
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TAR-T10335-10mg10mg£195.00
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TAR-T10335-25mg25mg£321.00
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TAR-T10335-50mg50mg£543.00
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Quantity:
TAR-T10335-100mg100mg£748.00
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This product comes from: United States.
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Further Information

Bioactivity:
Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM).
CAS:
1186430-60-3
Formula:
C23H24FN5
Molecular Weight:
389.47
Pathway:
Metabolism
Purity:
1
SMILES:
FC1=CC=C(C=C1)CN2C(=NC=3C=CC=CC32)N4CCC(N5N=CC(=C5)C)CC4
Target:
P45

References

1. Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.