BRD5648

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TargetMol
Product Code: TAR-T10608
Supplier: TargetMol
CodeSizePrice
TAR-T10608-1mg1mg£156.00
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TAR-T10608-5mg5mg£266.00
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TAR-T10608-1mL1 mL * 10 mM (in DMSO)£278.00
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TAR-T10608-10mg10mg£358.00
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TAR-T10608-25mg25mg£551.00
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TAR-T10608-50mg50mg£756.00
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TAR-T10608-100mg100mg£1,018.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
BRD5648 is an inactive (R)-enantiomer of BRD0705. BRD0705 is a GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM) and can be used in acute myeloid leukemia (AML) studies.
CAS:
2056261-42-6
Formula:
C20H23N3O
Molecular Weight:
321.424
Pathway:
Stem Cells; PI3K/Akt/mTOR signaling
Purity:
0.98
SMILES:
CC[C@]1(C2=CNNC2=NC2=C1C(=O)CC(C)(C)C2)c1ccccc1
Target:
GSK-3

References

1. Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). 2. Scolnick Edward, et al. Preparation of substituted pyrazoloquinolinones as paralog-?selective inhibitors of GSK3 kinases. US20160375006A1