TargetMol

BRM/BRG1 ATP Inhibitor-1

Product Code:
 
TAR-T10616
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10616-1mg1mg£436.00
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Quantity:
TAR-T10616-1mL1 mL * 10 mM (in DMSO)£527.00
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TAR-T10616-5mg5mg£724.00
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TAR-T10616-10mg10mg£1,058.00
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Quantity:
TAR-T10616-25mg25mg£1,540.00
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TAR-T10616-50mg50mg£2,054.00
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Quantity:
TAR-T10616-100mg100mg£2,745.00
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Further Information

Bioactivity:
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual Brahma homolog (BRM)/SWI/SNF related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2) and BRG1/SMARCA4 ATPase activity inhibitor (IC50s<0.005 μM).
CAS:
2270879-17-7
Formula:
C11H9F3N4O2S
Molecular Weight:
318.27
Pathway:
Chromatin/Epigenetic
Purity:
0.9968
SMILES:
OCc1cnc(F)cc1NC(=O)Nc1cc(ns1)C(F)F
Target:
Epigenetic Reader Domain

References

1. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172