EGFR-IN-8

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TargetMol
Product Code: TAR-T11162
Supplier: TargetMol
CodeSizePrice
TAR-T11162-1mg1mg£164.00
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TAR-T11162-5mg5mg£302.00
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TAR-T11162-1mL1 mL * 10 mM (in DMSO)£409.00
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TAR-T11162-10mg10mg£454.00
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TAR-T11162-25mg25mg£704.00
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TAR-T11162-50mg50mg£938.00
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TAR-T11162-100mg100mg£1,259.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
CAS:
2407957-87-1
Formula:
C32H23ClF3N7O4
Molecular Weight:
662.03
Pathway:
JAK/STAT signaling; Angiogenesis; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2nc(no2)-c2ccc(NC(=O)c3cccnc3)cc2Cl)ccc1NC(=O)C1CC1
Target:
EGFR; c-Met/HGFR

References

1. Dokla EME, et al. 1,2,4-Oxadiazole derivatives targeting EGFR and c-Met degradation in TKI resistant NSCLC. Eur J Med Chem. 2019 Aug 9;182:111607.