GSK2643943A

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TargetMol
Product Code: TAR-T11485
Supplier: TargetMol
CodeSizePrice
TAR-T11485-1mg1mg£101.00
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TAR-T11485-5mg5mg£142.00
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TAR-T11485-1mL1 mL * 10 mM (in DMSO)£149.00
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Quantity:
TAR-T11485-10mg10mg£189.00
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Quantity:
TAR-T11485-25mg25mg£325.00
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TAR-T11485-50mg50mg£464.00
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Quantity:
TAR-T11485-100mg100mg£651.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor (IC50: 160 nM for USP20/Ub-Rho).
CAS:
T11485
Formula:
C17H12FN3
Molecular Weight:
277.3
Pathway:
Ubiquitination; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9806
SMILES:
FC1=CC=CC(/C=C/C2=CC(NC(N)=C3C#N)=C3C=C2)=C1
Target:
DUB

References

1. Harrigan JA, et al.Deubiquitylating enzymes and drug discovery: emerging opportunities.Nat Rev Drug Discov. 2018 Jan;17(1):57-78. 2. Nishi Kumari, et al. Targeting the Ubiquitin Proteasome System in Cancer. Neoplasm. 2017 Dec.