LEQ506

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TargetMol
Product Code: TAR-T11838
Supplier: TargetMol
CodeSizePrice
TAR-T11838-1mg1mg£201.00
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TAR-T11838-5mg5mg£402.00
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TAR-T11838-1mL1 mL * 10 mM (in DMSO)£436.00
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TAR-T11838-10mg10mg£567.00
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Quantity:
TAR-T11838-25mg25mg£862.00
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TAR-T11838-50mg50mg£1,139.00
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Quantity:
TAR-T11838-100mg100mg£1,508.00
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TAR-T11838-500mg500mg£2,954.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
CAS:
1204975-42-7
Formula:
C25H32N6O
Molecular Weight:
432.572
Pathway:
Stem Cells
Purity:
0.9853
SMILES:
C[C@@H]1CN(CCN1c1cnc(cn1)C(C)(C)O)c1nnc(Cc2ccccc2)c(C)c1C
Target:
Smo

References

1. Lauressergues E, et al. Pharmacological evaluation of a series of smoothened antagonists in signaling pathways and after topical application in a depilated mouse model. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214. 2. Peukert S, et al. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened. ChemMedChem. 2013 Aug;8(8):1261-5.