ON 146040

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TargetMol
Product Code: TAR-T12310
Supplier: TargetMol
CodeSizePrice
TAR-T12310-1mg1mg£148.00
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TAR-T12310-2mg2mg£189.00
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TAR-T12310-5mg5mg£269.00
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TAR-T12310-1mL1 mL * 10 mM (in DMSO)£301.00
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TAR-T12310-10mg10mg£389.00
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TAR-T12310-25mg25mg£594.00
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TAR-T12310-50mg50mg£804.00
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TAR-T12310-100mg100mg£1,058.00
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TAR-T12310-500mg500mg£2,046.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
CAS:
1404231-34-0
Formula:
C24H23N7O3S
Molecular Weight:
489.55
Pathway:
Angiogenesis; Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
Purity:
0.9989
SMILES:
CN1CCN(CC1)c1ccc(Nc2ncc3NC(=O)C(Sc3n2)=Cc2ccc(cc2)[N+]([O-])=O)cc1
Target:
PI3K; Bcr-Abl

References

1. Stephen Cosenza, et al. Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K ?/? and BCR-ABL. Journal of Clinical Oncology 2014 32:15