STL127705

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TargetMol
Product Code: TAR-T13017
Supplier: TargetMol
CodeSizePrice
TAR-T13017-1mg1mg£164.00
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TAR-T13017-5mg5mg£303.00
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TAR-T13017-1mL1 mL * 10 mM (in DMSO)£338.00
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TAR-T13017-10mg10mg£436.00
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TAR-T13017-25mg25mg£675.00
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TAR-T13017-50mg50mg£922.00
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Quantity:
TAR-T13017-100mg100mg£1,219.00
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TAR-T13017-500mg500mg£2,368.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
STL127705 is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM.
CAS:
1326852-06-5
Formula:
C22H20FN5O4
Molecular Weight:
437.431
Pathway:
; PI3K/Akt/mTOR signaling; DNA Damage/DNA Repair
Purity:
0.9918
SMILES:
COc1ccc(CCNc2ncc3c(n2)[nH]c(=O)n(-c2cccc(F)c2)c3=O)cc1OC
Target:
DNA-PK;

References

1. Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.