TP-10

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TargetMol
Product Code: TAR-T13189
Supplier: TargetMol
CodeSizePrice
TAR-T13189-1mg1mg£145.00
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TAR-T13189-5mg5mg£229.00
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TAR-T13189-1mL1 mL * 10 mM (in DMSO)£254.00
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TAR-T13189-10mg10mg£306.00
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TAR-T13189-25mg25mg£482.00
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TAR-T13189-50mg50mg£667.00
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TAR-T13189-100mg100mg£914.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
CAS:
898563-00-3
Formula:
C26H19F3N4O
Molecular Weight:
460.46
Pathway:
Metabolism
Purity:
0.9848
SMILES:
FC(F)(F)Cn1cc(c(n1)-c1ccc(OCc2ccc3ccccc3n2)cc1)-c1ccncc1
Target:
PDE

References

1. Hamaguchi W, et al. Synthesis and in vivo evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors. Chem Pharm Bull (Tokyo). 2014;62(12):1200-1213. 2. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem