ZK168281
Code | Size | Price |
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TAR-T13404-5mg | 5mg | £1,894.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T13404-50mg | 50mg | £3,749.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T13404-100mg | 100mg | £5,211.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure antagonist of VDR (Kd of 0.1 nM). ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.
CAS:
186371-96-0
Formula:
C32H46O5
Molecular Weight:
510.715
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H]([C@H](C)C=C[C@@H](O)C3(CC3)C=CC(=O)OCC)[C@@]1(C)CCCC2=C/C=C1/C[C@@H](O)C[C@H](O)C1=C
References
1. Lempi?inen H, et al. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol Endocrinol. 2005 Sep;19(9):2258-72.