UC-514321

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TargetMol
Product Code: TAR-T13950
Supplier: TargetMol
CodeSizePrice
TAR-T13950-1mg1mg£139.00
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TAR-T13950-5mg5mg£230.00
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TAR-T13950-1mL1 mL * 10 mM (in DMSO)£254.00
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TAR-T13950-10mg10mg£373.00
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TAR-T13950-25mg25mg£582.00
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TAR-T13950-50mg50mg£784.00
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TAR-T13950-100mg100mg£1,058.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.
CAS:
299420-83-0
Formula:
C26H35NO5
Molecular Weight:
441.568
Pathway:
JAK/STAT signaling; Apoptosis; Stem Cells
Purity:
0.97
SMILES:
CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(N1CCOCC1)c1cc2OCOc2cc1O
Target:
Apoptosis; STAT

References

1. Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099.