TargetMol

7 α,25-Dihydroxycholesterol

Product Code:
 
TAR-T14063
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T14063-10mg10mg£390.00
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TAR-T14063-25mg25mg£747.00
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Quantity:
TAR-T14063-50mg50mg£1,106.00
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Further Information

Bioactivity:
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
CAS:
64907-22-8
Formula:
C27H46O3
Molecular Weight:
418.662
Pathway:
GPCR/G Protein; Metabolism
Purity:
0.98
SMILES:
[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O
Target:
EBI2/GPR183; Endogenous Metabolite

References

1. Liu C, et al. Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23. 2. Hannedouche S, et al. Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.