Acivicin
| Code | Size | Price |
|---|
| TAR-T14114-1mg | 1mg | £172.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Acivicin (AT-125), a natural product produced by Streptomyces sviceus, is a γ glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
CAS:
42228-92-2
Formula:
C5H7ClN2O3
Molecular Weight:
178.57
Purity:
0.98
SMILES:
N[C@@H]([C@@H]1CC(Cl)=NO1)C(O)=O
References
1. Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition?Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26.
2. Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5.