Allitinib

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TargetMol
Product Code: TAR-T14336
Supplier: TargetMol
CodeSizePrice
TAR-T14336-1mg1mg£200.00
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TAR-T14336-5mg5mg£335.00
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TAR-T14336-1mL1 mL * 10 mM (in DMSO)£340.00
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TAR-T14336-10mg10mg£470.00
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TAR-T14336-25mg25mg£670.00
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TAR-T14336-50mg50mg£962.00
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TAR-T14336-100mg100mg£1,259.00
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TAR-T14336-500mg500mg£2,440.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Allitinib (AST-1306) has anti-cancer activity?and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
CAS:
897383-62-9
Formula:
C24H18ClFN4O2
Molecular Weight:
448.88
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; JAK/STAT signaling
Purity:
0.9928
SMILES:
Fc1cccc(COc2ccc(Nc3ncnc4ccc(NC(=O)C=C)cc34)cc2Cl)c1
Target:
EGFR

References

1. Xie H, Lin L, Tong L et al. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo. PLoS One. 2011;6(7):e21487.