Aumitin

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TargetMol
Product Code: TAR-T14346
Supplier: TargetMol
CodeSizePrice
TAR-T14346-1mg1mg£171.00
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TAR-T14346-5mg5mg£322.00
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TAR-T14346-1mL1 mL * 10 mM (in DMSO)£348.00
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TAR-T14346-10mg10mg£470.00
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TAR-T14346-25mg25mg£707.00
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TAR-T14346-50mg50mg£978.00
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TAR-T14346-100mg100mg£1,291.00
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TAR-T14346-500mg500mg£2,456.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1], and it inhibits mitochondrial respiration by targeting complex I.
CAS:
946293-78-3
Formula:
C24H20ClN5O
Molecular Weight:
429.91
Pathway:
Autophagy;
Purity:
0.9877
SMILES:
Cc1cc(Nc2ccccc2)nc(Nc2ccc(NC(=O)c3ccccc3Cl)cc2)n1
Target:
Autophagy

References

1. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022.