CUR61414 hydrochloride
| Code | Size | Price |
|---|
| TAR-T15019L-1mg | 1mg | £287.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apop
CAS:
0
Formula:
C31H43ClN4O5
Molecular Weight:
587.15
Pathway:
GPCR/G Protein; Stem Cells
Purity:
0.9522
SMILES:
CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O.Cl
Target:
Hedgehog/Smoothened
References
1. Juliet A Williams, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.
2. Maria Frank-Kamenetsky. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol. 2002 Nov 6;1(2):10.