TargetMol

JH-VIII-157-02

Product Code:
 
TAR-T15612
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T15612-1mg1mg£229.00
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TAR-T15612-5mg5mg£409.00
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TAR-T15612-1mL1 mL * 10 mM (in DMSO)£417.00
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TAR-T15612-10mg10mg£575.00
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TAR-T15612-25mg25mg£858.00
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TAR-T15612-50mg50mg£1,155.00
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Quantity:
TAR-T15612-100mg100mg£1,532.00
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Further Information

Bioactivity:
JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L.
CAS:
1639422-97-1
Formula:
C28H27N5O2
Molecular Weight:
465.557
Pathway:
Tyrosine Kinase/Adaptors; Angiogenesis; Cytoskeletal Signaling
Purity:
0.98
SMILES:
CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn(CC(=O)N(C)C)c1
Target:
Microtubule Associated; ALK

References

1. Hatcher JM, et al. Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation. J Med Chem. 2015 Dec 10;58(23):9296-9308.