TargetMol

MB-07811

Product Code:
 
TAR-T16018
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16018-1mg1mg£227.00
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TAR-T16018-5mg5mg£422.00
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TAR-T16018-10mg10mg£589.00
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TAR-T16018-25mg25mg£863.00
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TAR-T16018-50mg50mg£1,179.00
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This product comes from: United States.
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Further Information

Bioactivity:
MB-07811 is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.
CAS:
852948-13-1
Formula:
C28H32ClO5P
Molecular Weight:
514.98
Pathway:
Endocrinology/Hormones
Purity:
0.9728
SMILES:
CC(C)c1cc(Cc2c(C)cc(OC[P@@]3(=O)OCC[C@H](O3)c3cccc(Cl)c3)cc2C)ccc1O
Target:
Thyroid hormone receptor(THR)

References

1. Cable EE, et al. Reduction of hepatic steatosis in rats and mice after treatment with aliver-targeted thyroidhormone receptor agonist. Hepatology. 2009 Feb;49(2):407-17. 2. Erion MD, et al. Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5.