Okadaic acid
| Code | Size | Price |
|---|
| TAR-T16381-1mg | 1mg | £3,323.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halichondria. Okadaic acid eliminates metazoan symbionts/parasites by apoptosis.
CAS:
78111-17-8
Formula:
C44H68O13
Molecular Weight:
805.015
Purity:
0.98
SMILES:
[H][C@]1(CC(C)=C[C@@]2(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O)O1)[C@H](C)C=C[C@H]1CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1
References
1. Bialojan C, et al. Inhibitory?effect?of a?marine-sponge?toxin,?okadaic acid, on?protein phosphatases. Specificity and kinetics. Biochem J.?1988 Nov 15;256(1):283-90.
2. McCluskey A, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem.?2002 Mar 14;45(6):1151-75.
3. Schr?der HC, et al. Okadaic?acid, an?apoptogenic?toxin?for?symbiotic/parasitic?annelids?in the?demosponge?Suberites?domuncula. Appl Environ Microbiol.?2006 Jul;72(7):4907-16.