Pironetin
| Code | Size | Price |
|---|
| TAR-T16543-1mg | 1mg | £790.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pironetin binds to α-tubulin and is an effective inhibitor of microtubule polymerization. It also has cell cycle arrest and antitumor activity. Pironetin is an α/β unsaturated lactone isolated from Streptomyces species.
CAS:
151519-02-7
Formula:
C19H32O4
Molecular Weight:
324.461
Pathway:
Cytoskeletal Signaling
Purity:
0.98
SMILES:
CC[C@@H]1C=CC(=O)O[C@@H]1C[C@@H](O)[C@H](C)[C@H](OC)[C@@H](C)CC=CC
Target:
Microtubule Associated
References
1. Kondoh M, et al. Cell cycle arrest and antitumor activity of pironetin and its derivatives. Cancer Lett. 1998 Apr 10;126(1):29-32.
2. Yang J, et al. Pironetin reacts covalently with cysteine-316 of ?-tubulin to destabilize microtubule. ] Nat Commun. 2016 Jun 30;7:12103.