TargetMol

Quarfloxin

Product Code:
 
TAR-T16703
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16703-1mg1mg£168.00
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TAR-T16703-5mg5mg£286.00
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TAR-T16703-1mL1 mL * 10 mM (in DMSO)£361.00
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TAR-T16703-10mg10mg£414.00
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TAR-T16703-25mg25mg£623.00
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TAR-T16703-50mg50mg£849.00
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TAR-T16703-100mg100mg£1,058.00
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This product comes from: United States.
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Further Information

Bioactivity:
Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.
CAS:
865311-47-3
Formula:
C35H33FN6O3
Molecular Weight:
604.686
Pathway:
Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Purity:
0.9976
SMILES:
CN1CCC[C@H]1CCNC(=O)c1cn2c3cc4ccccc4cc3oc3c(N4CCC(C4)c4cnccn4)c(F)cc(c23)c1=O
Target:
DNA/RNA Synthesis

References

1. Hald ?H, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2018 Dec 12.