Reldesemtiv

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TargetMol
Product Code: TAR-T16728
Supplier: TargetMol
CodeSizePrice
TAR-T16728-1mg1mg£221.00
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TAR-T16728-5mg5mg£389.00
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TAR-T16728-1mL1 mL * 10 mM (in DMSO)£422.00
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TAR-T16728-10mg10mg£544.00
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TAR-T16728-25mg25mg£830.00
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TAR-T16728-50mg50mg£1,099.00
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Quantity:
TAR-T16728-100mg100mg£1,460.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
Reldesemtiv is a selective activator of fast skeletal muscle troponin with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in the heart failure model.
CAS:
1345410-31-2
Formula:
C19H18F2N6O
Molecular Weight:
384.38
Purity:
0.98
SMILES:
C(NC=1N=CC(=CN1)N2C=C(C(N)=O)C=C2)[C@@]3(C[C@H](F)C3)C4=C(F)C=CC=N4

References

1. Hwee DT, et al. The small-molecule fast skeletal troponin activator, CK-2127107, improves exercise tolerance in a rat model of heart failure. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68. 2. Andrews JA, et al. CK-2127107 amplifies skeletal muscle response to nerve activation in humans. Muscle Nerve. 2018 May;57(5):729-734.