SPP-86

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TargetMol
Product Code: TAR-T16923
Supplier: TargetMol
CodeSizePrice
TAR-T16923-1mg1mg£103.00
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TAR-T16923-1mL1 mL * 10 mM (in DMSO)£148.00
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Quantity:
TAR-T16923-5mg5mg£148.00
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Quantity:
TAR-T16923-10mg10mg£195.00
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Quantity:
TAR-T16923-25mg25mg£322.00
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Quantity:
TAR-T16923-50mg50mg£470.00
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Quantity:
TAR-T16923-100mg100mg£651.00
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TAR-T16923-500mg500mg£1,291.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.
CAS:
1357349-91-7
Formula:
C16H15N5
Molecular Weight:
277.331
Pathway:
Apoptosis; Tyrosine Kinase/Adaptors
Purity:
0.9819
SMILES:
CC(C)n1nc(C#Cc2ccccc2)c2c(N)ncnc12
Target:
c-RET

References

1. Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.