TAS6417

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TargetMol
Product Code: TAR-T16996
Supplier: TargetMol
CodeSizePrice
TAR-T16996-1mg1mg£142.00
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TAR-T16996-5mg5mg£230.00
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TAR-T16996-1mL1 mL * 10 mM (in DMSO)£252.00
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TAR-T16996-10mg10mg£334.00
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TAR-T16996-25mg25mg£603.00
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TAR-T16996-50mg50mg£922.00
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TAR-T16996-100mg100mg£1,380.00
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TAR-T16996-500mg500mg£2,705.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).
CAS:
1661854-97-2
Formula:
C23H20N6O
Molecular Weight:
396.454
Pathway:
Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
Purity:
0.9919
SMILES:
CC1=C[C@@H](Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc21)NC(=O)C=C
Target:
Apoptosis; EGFR

References

1. Hasako S, et al. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations. Mol Cancer Ther. 2018 Aug;17(8):1648-1658.