TC-S 7005

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TargetMol
Product Code: TAR-T17008
Supplier: TargetMol
CodeSizePrice
TAR-T17008-1mg1mg£166.00
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TAR-T17008-2mg2mg£212.00
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TAR-T17008-5mg5mg£309.00
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TAR-T17008-1mL1 mL * 10 mM (in DMSO)£333.00
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TAR-T17008-10mg10mg£426.00
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TAR-T17008-25mg25mg£647.00
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TAR-T17008-50mg50mg£863.00
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TAR-T17008-100mg100mg£1,139.00
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TAR-T17008-500mg500mg£2,215.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
CAS:
1082739-92-1
Formula:
C21H17N3O3
Molecular Weight:
359.38
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9944
SMILES:
N([C@@H](C)C1=CC=CC=C1)C=2C=C3C(=NOC3=CN2)C=4C=C5C(=CC4)OCO5
Target:
PLK

References

1. Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5186-9. 2. Stephan Reinhard K?nzel, et al. Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation. bioRxiv 445098