TCS 21311
| Code | Size | Price |
|---|
| TAR-T17019-1mg | 1mg | £150.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKC?, and GSK3β (IC50s: 13, 68, and 3 nM, respectively). It displays >100-fold selectivity over JAK1, JAK2, and TYK2.
CAS:
1260181-14-3
Formula:
C27H25F3N4O4
Molecular Weight:
526.516
Pathway:
JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells; Angiogenesis; Cytoskeletal Signaling; Chromatin/Epigenetic
Purity:
0.98
SMILES:
CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F
Target:
GSK-3; JAK; PKC