TPA 023

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TargetMol
Product Code: TAR-T17144
Supplier: TargetMol
CodeSizePrice
TAR-T17144-1mg1mg£369.00
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TAR-T17144-1mL1 mL * 10 mM (in DMSO)£621.00
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TAR-T17144-5mg5mg£703.00
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TAR-T17144-10mg10mg£938.00
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Quantity:
TAR-T17144-25mg25mg£1,380.00
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TAR-T17144-50mg50mg£1,821.00
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Quantity:
TAR-T17144-100mg100mg£2,456.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
TPA 023 is a selective agonist of GABAA α2/α3 subtype (Kis = 0.19 - 0.41 nM).
CAS:
252977-51-8
Formula:
C20H22FN7O
Molecular Weight:
395.442
Pathway:
Membrane transporter/Ion channel; Neuroscience
Purity:
0.98
SMILES:
CCn1ncnc1COc1nn2c(nnc2cc1C(C)(C)C)-c1ccccc1F
Target:
GABA Receptor

References

1. Castner SA, et al. Reversal of ketamine-induced working memory impairments by the GABAAalpha2/3 agonist TPA023. Biol Psychiatry. 2010 May 15;67(10):998-1001. 2. Atack JR. Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023. Adv Pharmacol. 2009;57:137-85