Phe-Lys(Trt)-PAB

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TargetMol
Product Code: TAR-T18540
Supplier: TargetMol
CodeSizePrice
TAR-T18540-1mg1mg£123.00
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Quantity:
TAR-T18540-5mg5mg£177.00
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Quantity:
TAR-T18540-10mg10mg£222.00
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Quantity:
TAR-T18540-25mg25mg£345.00
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Quantity:
TAR-T18540-50mg50mg£462.00
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Quantity:
TAR-T18540-100mg100mg£630.00
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Quantity:
TAR-T18540-200mg200mg£871.00
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Quantity:
TAR-T18540-500mg500mg£1,259.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
CAS:
1116085-99-4
Formula:
C41H44N4O3
Molecular Weight:
640.828
Purity:
0.9787
SMILES:
N[C@@H](Cc1ccccc1)C(=O)N([C@@H](CCCCNC(c1ccccc1)(c1ccccc1)c1ccccc1)C(N)=O)c1ccc(CO)cc1

References

1. Abu Ajaj K, et al. Development of protein-binding bifunctional linkers for a new generation of dual-actingprodrugs. Bioconjug Chem. 2009 Feb;20(2):390-6. 2. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.