TargetMol

VU0359595

Product Code:
 
TAR-T21777
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T21777-1mg1mg£149.00
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Quantity:
TAR-T21777-5mg5mg£257.00
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TAR-T21777-10mg10mg£343.00
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TAR-T21777-25mg25mg£530.00
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TAR-T21777-50mg50mg£728.00
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Quantity:
TAR-T21777-100mg100mg£978.00
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Further Information

Bioactivity:
VU0359595 is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.
CAS:
1246303-14-9
Formula:
C25H29BrN4O2
Molecular Weight:
497.43
Pathway:
Metabolism
Purity:
0.98
SMILES:
O=C1N(C=2C(N1)=CC(Br)=CC2)C3CCN(C[C@@H](NC(=O)[C@H]4[C@@H](C4)C5=CC=CC=C5)C)CC3
Target:
Phospholipase

References

1. Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009;19(7):1916-1920. 2. Burkhardt U, et al. Phospholipase D is a target for inhibition of astroglial proliferation by ethanol. Neuropharmacology. 2014;79:1-9. 3. Tenconi PE, et al. High glucose-induced phospholipase D activity in retinal pigment epithelium cells: New insights into the molecular mechanisms of diabetic retinopathy. Exp Eye Res. 2019;184:243-257. 4. Berm?dez V, et al. Lipopolysaccharide-Induced Autophagy Mediates Retinal Pigment Epithelium Cells Survival. Modulation by the Phospholipase D Pathway. Front Cell Neurosci. 2019;13:154. Published 2019 Apr 24. 5. Jia X, et al. Gliotoxin promotes Aspergillus fumigatus internalization into type II human pneumocyte A549 cells by inducing host phospholipase D activation. Microbes Infect. 2014 Jun;16(6):491-501.