TargetMol

TASIN-1

Product Code:
 
TAR-T22632
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

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CodeSizePrice
TAR-T22632-1mg1mg£97.00
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TAR-T22632-5mg5mg£132.00
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TAR-T22632-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T22632-10mg10mg£177.00
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TAR-T22632-25mg25mg£298.00
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TAR-T22632-50mg50mg£436.00
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Quantity:
TAR-T22632-100mg100mg£610.00
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Quantity:
TAR-T22632-500mg500mg£1,219.00
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This product comes from: United States.
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Further Information

Bioactivity:
TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).
CAS:
792927-06-1
Formula:
C18H28N2O3S
Molecular Weight:
352.49
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9848
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCC(C)CC1
Target:
APC

References

1. Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149. 2. Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 May;17(5):943-951. 3. Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK. Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). J Med Chem. 2019 May 23;62(10):5217-5241.