KL001

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TargetMol
Product Code: TAR-T22891
Supplier: TargetMol
CodeSizePrice
TAR-T22891-1mg1mg£96.00
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TAR-T22891-5mg5mg£135.00
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TAR-T22891-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T22891-10mg10mg£164.00
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TAR-T22891-25mg25mg£230.00
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TAR-T22891-50mg50mg£306.00
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TAR-T22891-100mg100mg£422.00
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TAR-T22891-500mg500mg£860.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
CAS:
309928-48-1
Formula:
C21H22N2O4S
Molecular Weight:
398.48
Purity:
0.9885
SMILES:
CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1

References

1. Hirota T , Lee J W , John P , et al. Identification of Small Molecule Activators of Cryptochrome[J]. Science, 2012, 337(6098):1094-1097.