SR1664

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TargetMol
Product Code: TAR-T23389
Supplier: TargetMol
CodeSizePrice
TAR-T23389-1mg1mg£109.00
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TAR-T23389-2mg2mg£125.00
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TAR-T23389-5mg5mg£161.00
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TAR-T23389-1mL1 mL * 10 mM (in DMSO)£171.00
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TAR-T23389-10mg10mg£189.00
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TAR-T23389-25mg25mg£329.00
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TAR-T23389-50mg50mg£530.00
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TAR-T23389-100mg100mg£731.00
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TAR-T23389-500mg500mg£1,428.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity.
CAS:
1338259-05-4
Formula:
C33H29N3O5
Molecular Weight:
547.611
Pathway:
Metabolism; DNA Damage/DNA Repair
Purity:
0.9943
SMILES:
[H][C@@](C)(N=C(/O)c1ccc2n(Cc3ccc(cc3)-c3ccccc3C(O)=O)c(C)c(C)c2c1)c1ccc(cc1)N(=O)=O
Target:
PPAR

References

1. Marciano DP, Kuruvilla DS, Boregowda SV, et al. Pharmacological repression of PPAR? promotes osteogenesis. Nat Commun. 2015;6:7443. Published 2015 Jun 12. 2. Choi JH, et al. Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation. Nature. 2011 Sep 4;477(7365):477-81.