BX471

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TargetMol
Product Code: TAR-T2375
Supplier: TargetMol
CodeSizePrice
TAR-T2375-1mg1mg£99.00
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TAR-T2375-2mg2mg£111.00
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TAR-T2375-5mg5mg£137.00
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TAR-T2375-1mL1 mL * 10 mM (in DMSO)£144.00
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Quantity:
TAR-T2375-10mg10mg£177.00
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TAR-T2375-25mg25mg£274.00
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Quantity:
TAR-T2375-50mg50mg£429.00
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TAR-T2375-100mg100mg£589.00
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TAR-T2375-500mg500mg£1,139.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
BX471 is a potent, selective non-peptide CCR1 antagonist.
CAS:
217645-70-0
Formula:
C21H24ClFN4O3
Molecular Weight:
434.9
Pathway:
Microbiology/Virology; Immunology/Inflammation
Purity:
0.9994
SMILES:
C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O
Target:
CCR

References

1. Liang M, et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):192000-8. 2. Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9. 3. Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6. 4. Horuk R, et al. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem. 2001 Feb 9;276(6):4199-204. 5. Yang J Y, Zhang J, Lu R, et al. T cell?derived exosomes induced macrophage inflammatory protein?1?/? drive the trafficking of CD8+ T cells in oral lichen planus[J]. Journal of cellular and molecular medicine. 2020