Candesartan Cilexetil
Code | Size | Price |
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TAR-T2400-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2400-500mg | 500mg | £114.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2400-1g | 1g | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Candesartan Cilexetil is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation.
CAS:
145040-37-5
Formula:
C33H34N6O6
Molecular Weight:
610.671
Pathway:
Endocrinology/Hormones; Apoptosis
Purity:
1
SMILES:
CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Target:
Apoptosis; RAAS
References
1. See S, et al. Am J Health Syst Pharm,2000,7(8), 739-746.
2. Arumugam S, et al. Toxicology,2012, 291(1-3), 139-145.
3. Shirai K, et al. Mol Cell Biochem,2005, 269(1-2), 137-142.
4. Kanagawa R, et al. Jpn J Pharmacol,1997, 73(3), 185-190.
5. Kondo T, et al. Arzneimittelforschung,1996, 46(6), 594-600.