HIV-1 Inhibitor 18A

TargetMol
Product Code: TAR-T24141
Supplier: TargetMol
CodeSizePrice
TAR-T24141-1mg1mg£164.00
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TAR-T24141-1mL1 mL * 10 mM (in DMSO)£254.00
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TAR-T24141-5mg5mg£262.00
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Quantity:
TAR-T24141-10mg10mg£335.00
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Quantity:
TAR-T24141-25mg25mg£523.00
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Quantity:
TAR-T24141-50mg50mg£706.00
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Quantity:
TAR-T24141-100mg100mg£970.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Further Information

Bioactivity:
HIV-1 Inhibitor 18A specifically inhibits the entry of multiple HIV-1 isolates.
CAS:
331261-50-8
Formula:
C14H11N5O2S
Molecular Weight:
313.34
Pathway:
Microbiology/Virology; Proteases/Proteasome
Purity:
0.98
SMILES:
Oc1ccc(C=NNC(=O)Nc2cccc3nsnc23)cc1
Target:
HIV Protease

References

1. Berinyuy E, Soliman MES. Identification of Novel Potential gp120 of HIV-1 Antagonist Using Per-Residue Energy Contribution-Based Pharmacophore modelling. Interdiscip Sci. 2017 Sep;9(3):406-418. doi: 10.1007/s12539-016-0174-7. Epub 2016 May 10. PubMed PMID: 27165479. 2. Berinyuy E, Soliman ME. A broad spectrum anti-HIV inhibitor significantly disturbs V1/V2 domain rearrangements of HIV-1 gp120 and inhibits virus entry. J Recept Signal Transduct Res. 2016;36(2):119-29. doi: 10.3109/10799893.2015.1056307. Epub 2015 Oct 8. PubMed PMID: 26446906. 3. Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nat Chem Biol. 2014 Oct;10(10):845-52. doi: 10.1038/nchembio.1623. Epub 2014 Aug 31. PubMed PMID: 25174000; PubMed Central PMCID: PMC4231716. 4. Martin SF, Dorsey GO, Gane T, Hillier MC, Kessler H, Baur M, Math? B, Erickson JW, Bhat TN, Munshi S, Gulnik SV, Topol IA. Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors. J Med Chem. 1998 May 7;41(10):1581-97. PubMed PMID: 9572884.