TargetMol

K201

Product Code:
 
TAR-T24239
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24239-1mg1mg£115.00
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TAR-T24239-5mg5mg£160.00
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TAR-T24239-1mL1 mL * 10 mM (in DMSO)£180.00
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TAR-T24239-10mg10mg£197.00
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TAR-T24239-25mg25mg£279.00
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TAR-T24239-50mg50mg£380.00
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TAR-T24239-100mg100mg£531.00
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TAR-T24239-500mg500mg£1,075.00
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This product comes from: United States.
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Further Information

Bioactivity:
K201 is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors.
CAS:
1038410-88-6
Formula:
C25H33ClN2O2S
Molecular Weight:
461.06
Pathway:
Metabolism; Membrane transporter/Ion channel
Purity:
0.998
SMILES:
Cl.COc1ccc2SCCN(Cc2c1)C(=O)CCN1CCC(Cc2ccccc2)CC1
Target:
Calcium Channel

References

1. Darcy YL, Diaz-Sylvester PL, Copello JA. K201 (JTV519) is a Ca2+-Dependent Blocker of SERCA and a Partial Agonist of Ryanodine Receptors in Striated Muscle. Mol Pharmacol. 2016 Aug;90(2):106-15. 2. Toischer K, et al. K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Res Cardiol. 2010 Mar;105(2):279-87.