PF-562271

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TargetMol
Product Code: TAR-T2465
Supplier: TargetMol
CodeSizePrice
TAR-T2465-1mg1mg£114.00
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TAR-T2465-2mg2mg£133.00
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TAR-T2465-5mg5mg£174.00
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TAR-T2465-1mL1 mL * 10 mM (in DMSO)£185.00
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TAR-T2465-10mg10mg£201.00
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TAR-T2465-25mg25mg£290.00
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TAR-T2465-50mg50mg£389.00
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TAR-T2465-100mg100mg£550.00
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TAR-T2465-500mg500mg£1,083.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
CAS:
717907-75-0
Formula:
C21H20F3N7O3S
Molecular Weight:
507.49
Pathway:
Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint; Angiogenesis
Purity:
0.9765
SMILES:
CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
Target:
FAK; PYK2; CDK

References

1. Roberts WG, et al. Cancer Res, 2008, 68(6), 1935-1944. 2. Lim ST, et al. Cell Cycle, 2008, 7(15), 2306-2314. 3. Canel M, et al. Cancer Res, 2010, 70(22), 9413-9422. 4. Sun H, et al. Cancer Biol Ther, 2010, 10(1), 38-43. 5. Bagi CM, et al. Cancer, 2008, 112(10), 2313-2321.