TASIN-1 Hydrochloride

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TargetMol
Product Code: TAR-T24855
Supplier: TargetMol
CodeSizePrice
TAR-T24855-1mg1mg£166.00
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TAR-T24855-5mg5mg£266.00
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TAR-T24855-1mL1 mL * 10 mM (in DMSO)£276.00
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TAR-T24855-10mg10mg£348.00
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TAR-T24855-25mg25mg£544.00
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TAR-T24855-50mg50mg£744.00
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TAR-T24855-100mg100mg£1,002.00
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TAR-T24855-500mg500mg£1,942.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
TASIN-1 Hydrochloride is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
CAS:
1678515-13-3
Formula:
C18H29ClN2O3S
Molecular Weight:
388.95
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9984
SMILES:
Cl.COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCC(C)CC1
Target:
APC

References

1. Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149. 2. Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 May;17(5):943-951. 3. Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Sci Transl Med. 2016 Oct 19;8(361):361ra140. PubMed PMID: 27798265. 4. Cully M. Anticancer drugs: Exploiting a weakness in colorectal cancers. Nat Rev Drug Discov. 2016 Nov 29;15(12):820-821.