Auten-99 HBr
Code | Size | Price |
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TAR-T26684-1mg | 1mg | £166.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-5mg | 5mg | £266.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-1mL | 1 mL * 10 mM (in DMSO) | £294.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-10mg | 10mg | £385.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-25mg | 25mg | £597.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-50mg | 50mg | £820.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-100mg | 100mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T26684-500mg | 500mg | £2,103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Auten-99 HBr is a myotubularin phosphatase Jumpy inhibitor exerting potent neuroprotective effects. AUTEN-99 activates autophagy in cell cultures and animal models. AUTEN-99 appears to effectively penetrate through the blood-brain barrier, and impedes the progression of neurodegenerative symptoms in Drosophila models of Parkinson?s and Huntington?s diseases. Furthermore, the molecule increases the survival of isolated neurons under normal and oxidative stress-induced conditions. Thus, AUTEN-99 serves as a potent neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthy aging.
CAS:
1049780-58-6
Formula:
C17H15BrN2S
Molecular Weight:
359.29
Pathway:
Metabolism
Purity:
0.9837
SMILES:
Br.C1CN2C=C(SC2=N1)c1ccc(cc1)-c1ccccc1
Target:
Phosphatase
References
1. Erdos Attila, Vellai Tibor. Compounds For Enhancing Autophagy.WO/2018/130863
2. Kov?cs T, Billes V, Koml?s M, Hotzi B, Manz?ger A, Tarn?ci A, Papp D, Szikszai F, Sziny?kovics J, R?cz ?, Nosz?l B, Veszelka S, Walter FR, Deli MA, Hackler L Jr, Alfoldi R, Huzian O, Puskas LG, Liliom H, T?rnok K, Schlett K, Borsy A, Welker E, Kov?cs AL, P?d?r Z, Erd?s A, Legradi A, Bjelik A, Gulya K, Guly?s B, Vellai T. The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 Feb 16;7:42014. doi: 10.1038/srep42014. PubMed PMID: 28205624; PubMed Central PMCID: PMC5311965.