TargetMol

Hederacolchiside A1

Product Code:
 
TAR-T2P2806
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2P2806-1mg1mg£128.00
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TAR-T2P2806-5mg5mg£205.00
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TAR-T2P2806-10mg10mg£268.00
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TAR-T2P2806-1mL1 mL * 10 mM (in DMSO)£385.00
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TAR-T2P2806-25mg25mg£402.00
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TAR-T2P2806-50mg50mg£563.00
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TAR-T2P2806-100mg100mg£772.00
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  • Further Information
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Further Information

Bioactivity:
Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering membrane integrity and potential. Hederacolchiside A1 shows antiproliferation activities in three cancer cell lines with the IC50 value of 2.4 uM, it exhibits a preferential cytotoxicity on a pigmented melanoma cell line. It suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway.
CAS:
106577-39-3
Formula:
C47H76O16
Molecular Weight:
897.109
Pathway:
Microbiology/Virology; PI3K/Akt/mTOR signaling; Cytoskeletal Signaling; MAPK; Apoptosis
Purity:
0.9992
SMILES:
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](CO[C@H]2O[C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC=C3[C@@H]5CC(C)(C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H](O)[C@H]1O
Target:
Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR

References

1. Wang L , Wang Z , Su S , et al. Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins[J]. Carbohydrate Research, 2017, 442:9-16. 2. Barthomeuf C , Boivin D , Richard B?liveau. Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade[J]. Cancer Chemotherapy & Pharmacology, 2004, 54(5):432-440. 3. Delmas F, Giorgio C D , Elias R , et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro.[J]. Planta Medica, 2000, 66(04):343-347.