FIIN-3

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TargetMol
Product Code: TAR-T3466
Supplier: TargetMol
CodeSizePrice
TAR-T3466-1mg1mg£115.00
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TAR-T3466-2mg2mg£132.00
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TAR-T3466-5mg5mg£168.00
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TAR-T3466-1mL1 mL * 10 mM (in DMSO)£221.00
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Quantity:
TAR-T3466-10mg10mg£230.00
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Quantity:
TAR-T3466-25mg25mg£426.00
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TAR-T3466-50mg50mg£597.00
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TAR-T3466-100mg100mg£820.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
FIIN-3 is an irreversible inhibitor of FGFR.
CAS:
1637735-84-2
Formula:
C34H36Cl2N8O4
Molecular Weight:
691.61
Pathway:
JAK/STAT signaling; Tyrosine Kinase/Adaptors; Angiogenesis
Purity:
0.977
SMILES:
COc1cc(OC)c(Cl)c(NC(=O)N(Cc2ccc(NC(=O)C=C)cc2)c2cc(Nc3ccc(cc3)N3CCN(C)CC3)ncn2)c1Cl
Target:
EGFR; FGFR

References

Tan L et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A, 2014 Nov 11, 111(45):E4869-77