Tomivosertib

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TargetMol
Product Code: TAR-T3468
Supplier: TargetMol
CodeSizePrice
TAR-T3468-1mg1mg£118.00
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TAR-T3468-5mg5mg£209.00
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TAR-T3468-1mL1 mL * 10 mM (in DMSO)£222.00
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TAR-T3468-10mg10mg£275.00
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TAR-T3468-25mg25mg£454.00
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TAR-T3468-50mg50mg£626.00
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TAR-T3468-100mg100mg£860.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
eFT508 is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.
CAS:
1849590-01-7
Formula:
C17H20N6O2
Molecular Weight:
340.387
Pathway:
MAPK; Immunology/Inflammation; Apoptosis; Cell Cycle/Checkpoint
Purity:
0.9967
SMILES:
Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Target:
MNK; PD-1/PD-L1

References

Kevin R Webster, et al. eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL). Abstract#1554. Suarez M, Blyth G T, Mina A A, et al. Inhibitory effects of Tomivosertib in acute myeloid leukemia. Oncotarget. 2021, 12(10): 955. Suarez M, Blyth G T, Mina A A, et al. Inhibitory effects of Tomivosertib in acute myeloid leukemia[J]. Oncotarget. 2021, 12(10): 955.