Nazartinib

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TargetMol
Product Code: TAR-T3506
Supplier: TargetMol
CodeSizePrice
TAR-T3506-1mg1mg£95.00
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TAR-T3506-5mg5mg£128.00
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TAR-T3506-1mL1 mL * 10 mM (in DMSO)£134.00
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TAR-T3506-10mg10mg£168.00
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TAR-T3506-25mg25mg£229.00
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TAR-T3506-50mg50mg£369.00
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TAR-T3506-100mg100mg£517.00
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TAR-T3506-500mg500mg£1,050.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.
CAS:
1508250-71-2
Formula:
C26H31ClN6O2
Molecular Weight:
495.02
Pathway:
Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
CN(C)CC=CC(=O)N1CCCC[C@H](C1)n1c(NC(=O)c2ccnc(C)c2)nc2cccc(Cl)c12
Target:
EGFR

References

Jia Y, et al. Cancer Res. 2016, 76(6):1591-602. G?rald Lelais, et al. J Med Chem. 2016, 59(14), pp 6671-6689