THZ1 2HCl

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TargetMol
Product Code: TAR-T35332
Supplier: TargetMol
CodeSizePrice
TAR-T35332-1mg1mg£111.00
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TAR-T35332-5mg5mg£144.00
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TAR-T35332-1mL1 mL * 10 mM (in DMSO)£208.00
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TAR-T35332-10mg10mg£211.00
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TAR-T35332-25mg25mg£361.00
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TAR-T35332-50mg50mg£470.00
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TAR-T35332-100mg100mg£610.00
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TAR-T35332-200mg200mg£871.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
THZ1 2HCl is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a variety of cancer cell lines.
CAS:
2095433-94-4
Formula:
C31H30Cl3N7O2
Molecular Weight:
638.98
Pathway:
Cell Cycle/Checkpoint
Purity:
0.9833
SMILES:
O=C(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CNC5=C4C=CC=C5)=C(Cl)C=N3)=CC=C2)=O)C=C1)C=CCN(C)C.Cl.Cl
Target:
CDK

References

Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015 Aug 20;59(4):576-87.