TargetMol

Desmethylanethol trithione

Product Code:
 
TAR-T3560
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3560-5mg5mg£103.00
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Quantity:
TAR-T3560-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T3560-10mg10mg£116.00
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TAR-T3560-25mg25mg£149.00
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Quantity:
TAR-T3560-50mg50mg£204.00
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Quantity:
TAR-T3560-100mg100mg£283.00
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Further Information

Bioactivity:
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
CAS:
18274-81-2
Formula:
C9H6OS3
Molecular Weight:
226.33
Pathway:
Tyrosine Kinase/Adaptors; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Angiogenesis
Purity:
0.9823
SMILES:
Oc1ccc(cc1)-c1cc(=S)ss1
Target:
VEGFR; Akt

References

Hasegawa U,et al. Hydrolysis-Sensitive Dithiolethione Prodrug Micelles. Macromol Biosci. 2015 Nov;15(11):1512-22.